Groxmaleenhancement Gro X Male

Heat shock protein (HSP90) belongs to a family of molecular chaperones which are rapid and abundantly induced by stresses. HSP90 plays a crucial role in stabilizing denatured proteins that have become misfolded or unfolded because of cellular stress and by aiding in their re-folding. So far, many of the proteins identified as HSP90 clients are key components of the oncogenic phenotype involved in controlling many of the hallmarks of cancer.

Inhibiting Hsp90 has the potential to affect all the hallmarks of cancer, making it an exciting potential therapeutic target. HSP90 inhibitors that bind the ATP binding pocket standing on the N-terminal of HSP90 have resulted in degradation of HSP90 client proteins through the ubiquitin proteasome pathway. The natural product of HSP90 inhibitors geldanamycin and radicicol can exert their antitumor function by blocking the intrinsic ATPase activity of HSP90, leading to degradation of HSP90 client proteins. Thus, HSP90 inhibition provides an important pharmacological platform for anticancer therapy.